Cell & Gene - Resources

03/04/24 - Scarlet Therapeutics uses genetic manipulation of red blood cells to carry a higher load of therapeutic proteins to help treat rare metabolic diseases.

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Cell Line Development & Engineering

UNIVERCell: Engineering Red Blood Cells for Targeted Therapy

Scarlet Therapeutics uses genetic manipulation of red blood cells to carry a higher load of therapeutic proteins to help treat rare metabolic diseases.

Cell Line Development & Engineering

Enhancing Gene Editing Efficiency: Multi-Tailed mRNA Integration in CRISPR-Cas9 Systems

A study conducted by the Broad Institute and the Massachusetts Institute of Technology (MIT) demonstrated that when multi-tailed mRNAs were integrated into a CRISPR-Cas9 system they proved to be more efficient gene editors than unmodified mRNA.

Cell Therapy Development

Cell Therapy for Solid Tumors: An Innovative Approach to Cancer Treatment

Cell therapy for solid tumours is an innovative cancer treatment that uses a patient's own immune cells or donor cells to fight cancer, but its effectiveness varies by tumour type and patient's immune system. Although it offers new hope, it poses risks such as cytokine release syndrome and neurotoxicity. Recent advancements have led to better targeting, combination therapies, and next-generation treatments, with future research aimed at improving safety, effectiveness, and accessibility, potentially revolutionising cancer care.

Gene Therapy Development

Post-Event Proceedings – Gene Therapy Development & Manufacturing 2023

Concise and insightful summaries of presentations delivered by prominent thought leaders at Gene Therapy Development & Manufacturing 2023.

Cell Therapy Development

Advancing Melanoma Treatment: The FDA Gives Lifileucel The Greenlight in Historic Cell & Gene Therapy Breakthrough

The Food and Drug Administration (FDA) approved lifileucel, a one-of-a-kind T-cell therapy developed by Iovance Biotherapeutics for treating melanoma.

Cell Therapy Development

Spotlight On: Lindsay Davies, Chief Scientific Officer of NextCell Pharma

We caught up with Lindsay Davies, Chief Scientific Officer of NextCell Pharma, to hear about to hear about the latest advancements in stromal cell therapy in anticipation of her presentation at our Cell & Gene 2024 Congress this November.

Top R&D Stories of 2023

Through captivating articles, insight pieces, and spotlight interviews, we delve into the remarkable innovations, breakthroughs, and scientific marvels that have defined the landscape of research over the past year.

Tissue Engineering & 3D Models

Putting Menopause on Hold: Could Ovarian Cryopreservation Prevent Menopause?

Ovarian cryopreservation could prolong fertility, paving the way for a breakthrough in women’s reproductive freedom

Preserving Life's Potential: methods and conditions of cryopreservation

Cryopreservation is a key technology in medicine, biotechnology, and conservation, enabling the preservation of biological materials at ultra-low temperatures for future use. It supports medical treatments, scientific research, and species conservation by maintaining the genetic integrity of cells, tissues, and organs. Cell & Gene by Oxford Global explores its mechanisms, methodologies, applications, and the future directions this essential technology is headed towards.

Gene Therapy Development

Curing HIV with cell & gene therapy?

It is now possible to live a long and near normal life with HIV, but what is the likelihood of a permanent cure?

Gene Therapy Development

Safety in Viral Vectors and Viral Clearance: Ensuring Efficacy and Security in Biopharmaceuticals

We discuss the challenges and safety measures in using viral vectors for gene therapies, focusing on vector selection, safety testing, quality control, and contamination prevention, highlighting their importance for the success of advanced medical treatments.

Cell & Gene Therapy Manufacturing

Proactive Approaches to Cell Culture Media and Process Control Strategies

Merck invests $25 million in a Kansas cell culture media plant, aiming to meet rising demand for advanced therapeutics while aligning with sustainability goals.

Cell & Gene Therapy Manufacturing

In Conversation With… Sophie Mountcastle, Network Manager, Innovation Hubs for Gene Therapies

Here, we discuss the crucial role of a collaborative network for gene therapy development across the UK and some of the successes seen to date.

Stem Cell Development & Manufacturing

Comparing Allogeneic and Autologous Stem Cell Transplantation Approaches

While both allogeneic and autologous cell therapies have seen a recent boom, the two approaches differ in terms of scale and customisation.

Upstream & Downstream Bioprocessing

Improving Control Strategies for Bioprocessing & Cell Culture

Discover advanced monitoring, environmental controls, mathematical models, PAT tools, and sensor technologies shaping the future of biopharmaceuticals

Stem Cell Development & Manufacturing

Applications of Stem Cells in Personalised Medicine

Novel applications of stem cells drive personalized medicine, tailoring treatments to each patient's unique profile. Explore groundbreaking applications for more effective, individualized therapies.

Cell & Gene Therapy Manufacturing

AppNote CBM Highthroughput AAV Viral Titering using Nano-Plate Based Digital PCR

Cell & Gene Therapy Manufacturing

Automated Isolation of Cells into Low Volumes for scWGA

Cell & Gene Therapy Manufacturing

Automated and Gentle Isolation of Single Cells for Efficient Cloning of hiPSCs

Cell & Gene Therapy Manufacturing

Cellular Insights Guide Discoveries

Cell & Gene Therapy Manufacturing

CERO - A Benchtop Incubator and Bioreactor

Cell & Gene Therapy Manufacturing

Cytokine Guide for Researchers

Cell & Gene Therapy Manufacturing

Cytokine Master Booklet Compact

Cell & Gene Therapy Manufacturing

Comprehensive CAR-T Therapy Development Solutions

Cell & Gene Therapy Manufacturing

Custom Services to Advance Drug Discovery

Cell & Gene Therapy Manufacturing

Digital PCR Applications and Gene Expression

Cell & Gene Therapy Manufacturing

Digital PCR for Sensitive Research Applications

Cell Line Development & Engineering

Does Plate Choice Change Sampling Accuracy

Cell & Gene Therapy Manufacturing

Exploring the Effects of Insulin on Viral Vectors Production in HEK293 Cells

Cell & Gene Therapy Manufacturing

Handling and Delivering Single Cells

Cell & Gene Therapy Manufacturing

Improve Your Upstream Manufacturing with Recombinant Insulin

Cell & Gene Therapy Manufacturing

Identifying Highly Potent TNF-a Secretors

Cell & Gene Therapy Manufacturing

Immune Cell-Mediated Killing of A549 Cancer Target Cells in Real-Time

Cell & Gene Therapy Manufacturing

How Current and New Technologies can Overcome Challenges in Adherent Scale-Up

Cell & Gene Therapy Manufacturing

Monitoring Cell Attachment and Tight Junctions in the Same Assay

Cell & Gene Therapy Manufacturing

Next Level Live-Cell Kinetic and Phenotypic Assays

Cell & Gene Therapy Manufacturing

Optimising CHO-K1 Fed-Batch Cell Culture Mediums for mAb Production

The Chinese Hamster Ovary (CHO) cell line is widely used to produce recombinant proteins due to its high growing capacity and productivity.

Cell & Gene Therapy Manufacturing

Orbital Shaken Benchtop Bioreactor for Single-Use Bags

Cell & Gene Therapy Manufacturing

Recombinant Protein and Antibody Production

Cell & Gene Therapy Manufacturing

Reagents for Oncology Research

Cell & Gene Therapy Manufacturing

Reagents for Drug Target Research

Cell & Gene Therapy Manufacturing

Quantifying Individual Cells That Secrete Cytokines

Cell & Gene Therapy Manufacturing

Rapidly Identifying Active Natural Killer Cells

Cell & Gene Therapy Manufacturing

Rapid and High Throughput Recombinant Antibody Production

Cell & Gene Therapy Manufacturing

Revealing and Retrieving Highly Potent IFN-y Secretors

Cell & Gene Therapy Manufacturing

Scaling Adherent Cell Culture with Corning HYPER Technology

Cell & Gene Therapy Manufacturing

Shorten the Path to Your Next Life-Changing Breakthrough

Cell & Gene Therapy Manufacturing

Seeding, Expanding, and Harvesting Stem Cells

Stem Cell Development & Manufacturing

Spinal Stem Cells 'Lure' Tumours to the Spine, Study Shows

An animal model study suggests that cells produced by breast cancer preferentially metastasize to the spine over other bones in the body, with key proteins identified as affecting spinal tropism.

Cell & Gene Therapy Manufacturing

The Next Level of Live-Cell Analytics

Cell & Gene Therapy Manufacturing

Toolkits for CAR-NK Therapy Targets

Cell & Gene Therapy Manufacturing

The Perfect Solution for Shaken Cultivation Processes

Cell & Gene Therapy Manufacturing

Unprecedented Flexibility for HTS Automated Patch Clamp

Cell Therapy Development

In Conversation With... Marta Barisa, Senior Research Fellow at UCL

Here, we speak to Marta Barisa, Senior Research Fellow at UCL, about switchable CAR-Ts and therapies for solid tumours.

Tissue Engineering & 3D Models

The Seed and Soil Hypothesis for the Pathogenesis of Cancer Metastases

While the preferential spread of tumours to specific parts of the body has been acknowledged for over a century, more accurate understandings of preferential metastasis have developed with an awareness of tumour biology.

Tissue Engineering & 3D Models

Investigating Organoids and Spheroids as 3D Culture Systems

3D models like organoids, spheroids, and organ-on-chip systems recreate human organ architecture and physiology, aiding research, drug development, and disease modelling.

Cell Therapy Development

Revolutionising Biomedicine: How AI Techniques and Applications enhance 3D Modeling in Cell & Gene Therapy and Drug Development

Discover the transformative role of AI in the world of biotechnology. Dive deep into its synergy with 3D modeling, revealing groundbreaking advancements in cell & gene therapy and faster, more efficient drug development cycles.

Navigating the Pharma R&D Regulatory Landscape 2023

Our ‘Navigating the Regulatory Landscape' eBook has been designed to provide you with invaluable insights into the intricacies of regulations & policies surrounding the challenges and opportunities of Real-World Data, genome editing, biomedical informatics, manufacturing and many more.

Cell Therapy Development

How Adaptimmune's T-Cell Therapy Development Pipeline Became a Commercialisation Success Story

Adaptimmune has developed from a strategic collaboration with GSK and embarked on a highly successful journey towards developing cancer immunotherapy treatments.

Cell Therapy Development

Droplet Compatibility of Xdrop DE20 and DE50 Production

Cell Therapy Development

Fast Encapsulation of Cells and DNA for Downstream Analysis

Cell Therapy Development

Retrieving Potent IFN-y Secretors via a Single-Cell Format Workflow

Cell Therapy Development

Technical Note for the Viability of DE20 and DE50 Droplets

Gene Therapy Development

Viral Vectors in Molecular Biology and Gene Therapy

Adeno-associated viral (AAV) vectors dominate gene therapy due to their efficiency and safety, although challenges remain in addressing toxicity and expanding applications.

Gene Therapy Development

Innovation Hubs for Gene Therapies: Advancing the Academic-Led Clinical Development of Novel Gene Therapies

The UK's cell and gene therapy sector is on the threshold of becoming a global leader in the field. While present challenges include the supply of equipment and skills gaps, Innovation Hubs aim to bridge these through collaboration.

Cell & Gene Therapy Manufacturing

Innovative Financial Strategies in Gene Therapy: A Shift Towards Sustainable Access

Discover the key strategies and financial nuances of gene therapy like outcome-driven contracts, payment plans, and shared financial agreements

Stem Cell Development & Manufacturing

Wiping an iPS Cell's Epigenetic Memory With TNT

Transient-native-transient reprogramming enables researchers to sidestep the differentiation quirks which can complicate the use of induced pluripotent stem cells by resetting their epigenetic memory.

Stem Cell Development & Manufacturing

Lipid Found in Breast Milk May Reduce Cerebral Palsy in Infants

A study from Duke University found that a lipid present in breast milk promotes a process leading to the generation of new brain cells, which could potentially aid in the repair of damaged white matter in infants with cerebral palsy.

Cell & Gene Therapy Manufacturing

Sustainability in Cell Therapy Manufacture: Improving Process Efficiency for Cell Line Development

Improving process efficiency is a key approach to factor in when looking at how cell therapy manufacture can be made more sustainable.

Cell Therapy Development

BrainStorm Hope to Mimic Biogen's Accelerated Approval of ALS Drug

The biotech company BrainStorm is seeking regulatory approval from the FDA for its cell therapy, NurOwn, which has been developed for the treatment of ALS.

Gene Therapy Development

Replacing the EU's Clinical Trials Directive: A Sea Change in Clinical Trial Execution

The EU's Clinical Trials Regulation has replaced the union's former Clinical Trials Directive, introducing a centralised application process which aims to ensure consistent timelines for clinical trial reviews.

Tissue Engineering & 3D Models

3D Cell Model Approaches for Disease Monitoring and Detection

Given the widespread incidence of cancers and cardiovascular diseases, having sufficient means to model their behaviour is vital to the development of new treatments. Maintaining tissue contexts in disease modelling is crucial for developing a comprehensive understanding of how different diseases behave.

Cell & Gene Therapy Manufacturing

CAR T-REX Aims to Bolster Anti-Tumoural Immune Response

An international European consortium has received a â‚¬2.7m grant to improve the safety and effectiveness of CAR-T cell therapies for solid tumours. If successful, the grant could massively improve treatment outcomes for patients.

Gene Therapy Development

Tracking Fibonacci Spirals in Plant Evolution and Morphology

Examples of Fibonacci spirals in nature include monkey puzzle trees, the double helix of human DNA, and even certain atmospheric patterns. Now, a new study from the University of Edinburgh suggests that the presence of these patterns in early plants may not be as ubiquitous as previously thought.

Gene Therapy Development

Accelerate Your Cell and Gene Therapy Analytics

Gene Therapy Development

Biocair - Advanced Cold Chain Packaging Options

Gene Therapy Development

Biocair - Delivering Personalised Supply Chains for Autologous Cell Therapies

Gene Therapy Development

Biocair - Your Partner for Life Science Logistics

Gene Therapy Development

Ella - Precision Multiplexing Made Simple

Gene Therapy Development

Identifying Highly Potent TNF-Alpha Secreting T Cells from Blood Samples

Gene Therapy Development

Imaged cIEF, CE-SDS, and Imaged cIEF Fractionation

Gene Therapy Development

Localising Lentiviral Transduction-Inserted CAR Cassettes in T Cells Using Xdrop

Gene Therapy Development

Jess - Your Complete Protein Analysis Solution

Gene Therapy Development

Professional Assay Services Offers GCLP-Compliant RNAscope, BASEscope, and miRNAscope

Gene Therapy Development

Qualifying Individual Cells in a Cytokine Secretion Assay

Gene Therapy Development

Rapidly Identifying Active Natural Killer Cells Using an Xdrop Single-Cell Format Assay Based on Double-Emulsion Droplets

Gene Therapy Development

Revealing and Retrieving Highly Potent IFN-y Secretors Using an Xdrop Single-Cell Format Workflow

Gene Therapy Development

Simplifying Transgene Insertion Analysis with Xdrop Sort

Stem Cell Development & Manufacturing

Zebrafish Models May Hold the Answer to Cell Dedifferentiation

Traditionally, cell fate and differentiation were considered to be a one-way journey. However, recent research using animal models like zebrafish has challenged this perspective.

Gene Therapy Development

Wilhelm Johannsen, Beans, and the Origins of Genotype and Phenotype

We spend a lot of time discussing new cell and gene therapies, as well as their implications for future treatment. But where did the term ‘gene' come from?

Tissue Engineering & 3D Models

3D Cell Cultures: From Disease Modelling to Toxicology

3D cell modelling can help develop understandings of disease pathologies, facilitating the investigation of how tissues react to certain treatments without causing undue harm or risk to the patients who need them.

Stem Cell Development & Manufacturing

Induced Pluripotent Stem Cells to be Manufactured on the ISS

With evidence suggesting that microgravity conditions may be best for growing and developing pluripotent stem cells, a team of astronauts aboard the International Space Station are set to test this hypothesis.

Cell & Gene Therapy Manufacturing

Crossing the Pond: Key Considerations for Stateside Biotechs Looking to the UK and Europe

Among the challenges faced by US biotechs looking at setting up in Europe, regulatory and cultural differences are chief among them. However, the strong tradition of scientific research and high standard of medical care across the Atlantic makes it worth the effort.

Cell Therapy Development

Biosafety Services - Health Inspired, Quality Driven

Tissue Engineering & 3D Models

Cardiff University Builds Lego 3D Bioprinter Capable of Synthesising Human Skin, Makes Blueprints Open Access

Blueprints for the bioprinter have been made open-access, to ensure greater freedom of use with the device at a time when research funding is harder to come by.

Tissue Engineering & 3D Models

3D Cell Spheroid Growth Using Sphericalplates 5D

Tissue Engineering & 3D Models

A Guide to Sodium Alginate Bioprinting

Tissue Engineering & 3D Models

Automated 3D Cell Culture and Automated Workstations

Tissue Engineering & 3D Models

Allevi 3 - Versatile Lab-Adapted Bioprinting

Tissue Engineering & 3D Models

Allevi Bioprinting Customised Solutions

Tissue Engineering & 3D Models

Allevi 1 - Designed to do More for Less

Tissue Engineering & 3D Models

Allevi 2 - Small but Mighty

Tissue Engineering & 3D Models

Cell Biology Workflows

Tissue Engineering & 3D Models

Differentiation of Embryonic and Induced Pluripotent Stem Cells

Tissue Engineering & 3D Models

Immunology Research-Related Cytokine Products

Tissue Engineering & 3D Models

Multivascular Networks and Functional Intravascular Topologies

Tissue Engineering & 3D Models

Newcells Products and Services

Tissue Engineering & 3D Models

PeproGMP Cytokines - Advancing Manufacturing Capabilities

Tissue Engineering & 3D Models

Repligut Planar Kits

Tissue Engineering & 3D Models

Screening Drug Efficacy in 3D

Tissue Engineering & 3D Models

RepliGut Model Systems

Tissue Engineering & 3D Models

RepliGut Custom Services

Tissue Engineering & 3D Models

Sequential Analysis in 3D Cell Cultures

Tissue Engineering & 3D Models

Tumour-on-a-Chip with Bioprinted Blood

Tissue Engineering & 3D Models

The Building Blocks of Organoid Research

Cell & Gene Therapy Manufacturing

Healthcare Data Platforms: Expert Tips on Integrating Digitalisation with Cell and Gene Manufacturing

Developers looking to integrate digitalisation approaches into their pipeline should ensure that they choose a sensible architecture, rather than simply automating for the sake of it.

Stem Cell Development & Manufacturing

Gene Knockout Mice in Disease Modelling

Over the past 50 years, rare disease research has paved the way for medical breakthroughs such as allogeneic stem cell transplantation. Other focuses have included the identification of potential drug targets by analysing cellular and molecular pathways.

Gene Therapy Development

Approved Gene Therapy Products Brought to Market Through the use of AI

Many of the biggest roadblocks in gene therapy development can be removed by tapping into longitudinal datasets facilitated by AI techniques and machine learning, tracking the real-world progress of clinical trial participants.

Cell & Gene Therapy Manufacturing

Metabolic Modelling and Machine Learning Technologies in Cell and Gene Manufacturing

Integrating PAT into metabolic modelling can help optimise the product obtained from cell cultures, augmenting the manufacturing process.

Cell & Gene Therapy Manufacturing

Cell and Gene Manufacturing Approaches and Winning Strategies for Commercialisation and Scale-Up

With a host of factors to consider in cell and gene manufacture, upscaling is still no small task. However, as industry experience accumulates and new technologies arrive on the market, there are an increasing number of options for developers looking to get their therapeutic on the road to the clinic.

Gene Therapy Development

CGT Manufacturing: Key Considerations for Implementing AI/ML Approaches

AI/ML approaches are not some miracle ‘one size fits all' fix-all for delays and holdups in CGT manufacture, but the proper implementation of deep learning approaches and data interpretation may help speed up development.

Cell Therapy Development

Regulation and Policy Interview with Scott Burger, Principal of Advanced Cell and Gene Therapy

Scott Burger, Principal of Advanced Cell and Gene Therapy, discusses some of the recent trends in regulation and policy surrounding cell and gene therapy development.

Cell & Gene Therapy Manufacturing

AI in Gene Therapy: How Could Machine Learning Approaches Reshape Therapeutic Development?

As more developers bring their cell and gene therapy products to industry regulators, the need to drive cost and process efficiencies is on track to keep growing. Across the board, AI and machine learning approaches have the potential to streamline many aspects of development.

Cell Therapy Development

CHO Cells and Engineering Cell Line Approaches: Addressing Challenges in Manufacturing

Regulatory approval is, as ever, a crucial factor to bear in mind during the later phases of clinical trials. Regardless of the cell line approach chosen, keeping a consistent process and product output is key for establishing a successful project without it being hamstrung at the final hurdle.

Cell & Gene Therapy Manufacturing

Industry Insights Into the FDA's Plans for Revised Gene Therapy Approval Approaches

Some additional measures announced include the launch of the Cell and Gene Therapy Access Model, as well as the interpolation of RWE into trials and a potential move away from animal models in validating treatment efficacy.

Gene Therapy Development

FDA Pursues Accelerated Approval Path Following Cell and Gene Therapy Backlog

The announcement comes with the news that the cell and gene therapy manufacturing market is now worth US$ 19.3 billion, with a compound annual growth rate (CAGR) of 29% between 2022 and 2023.

Cell Therapy Development

Jemperli Granted FDA Approval in Endometrial Cancer Applications

Following FDA approval for the use of Jemperli in the context of patients with dMMR recurrent or advanced scenarios, the therapeutic's applications are being investigated in registrational enabling studies as monotherapy and as part of combination regimens.

Cell Therapy Development

Senti Streamline Their CAR-NK Cell Therapy Program to Focus on Acute Myeloid Leukaemia

By dropping down from three to two ongoing cell therapies in clinical development, Senti aims to ensure its current financial reserves last into 2024.

Gene Therapy Development

Fortunes Brighten for Bluebird Bio as Cash Runway Extended to 2024

After a rocky year, bluebird bio's approval journey for a treatment for sickle cell disease looks to be back on track, with the company generating more funds by selling shares.

Cell Therapy Development

Funding Boost Announced for Experimental Cancer Medicine Centres

Potential treatments which may benefit from the funding increase include CAR-T cell therapies and checkpoint inhibitors, with the end goal of clinical use in cancer patients.

Cell Therapy Development

Good Manufacturing Practices: Overcoming Regulatory Approval Hurdles

Securing regulatory approval is often the end goal in the development of a new therapeutic product. But what steps can be taken to avoid some of the common curveballs encountered in the industry?

Tissue Engineering & 3D Models

In Conversation With...Stefan Przyborski, Professor, Durham University

In this video Q&A we discuss Stefan's recent work with bioengineered human tissues and the challenges to adopting 3D cell culture technologies in research.

Tissue Engineering & 3D Models

Apical-Out Organoids: A Novel Strategy to Control the Polarity of Organoids Closing

Genentech are developing several complex gastrointestinal in vitro models, including the innovative apical-out organoids.

Cell & Gene Therapy Manufacturing

Q &A with Shilpi Rajoria

An interview Shilpi Rajoria, Director QC Analytical Testing at Bristol Myers Squibb.

Tissue Engineering & 3D Models

Understanding the Capabilities of 3D Bioprinting for Cell and Gene Therapy

Exploring academic perspectives on 3D bioprinting techniques for cancer and disease indication models.

Tissue Engineering & 3D Models

Advanced and Predictive 3D Cell Culture Models

Elodie Vandenhaute, Project Director at HCS Pharma, leads a discussion group on utilising multi-cell type models to understand diseases, cells, and therapeutic mechanisms.

Upstream & Downstream Bioprocessing

Accelerating Upstream Process Development with Direct CQA and Media Analysis Feedback

Upstream Bioprocess Development.

Cell Line Development & Engineering

Experience the Next Generation in Clonality

Explore the future of single cell seeding.

Tissue Engineering & 3D Models

Using Cancer Organoids to Discover New Therapeutic Targets

The lack of predictive models is a highly limiting factor in the efficacy of projects designed to find new therapeutic targets. Cutting-edge organoid models may be the key to overcoming these challenges and could improve the prediction candidate drug molecules' clinical success.

Cell & Gene Therapy Manufacturing

Overcoming the Challenges in Cell Therapy Manufacturing

Udayanath Aich, Director at Bristol Myers Squibb, leads a Discussion Group on leveraging advanced technologies and biologics to mitigate challenges.

Cell & Gene Therapy Manufacturing

Looking into the Crystal Ball: The Future of Disruptive Cell and Gene Therapy Manufacturing

What will the future hold for autologous cell and gene therapy manufacturing? Tigen Pharma SA, share their predictions on the prospect of disruptive innovation for the industry.

Oxford Global's R&D Key 40 Stories 2022

Download a copy of the R&D Key 40 Stories 2022 eBook today.

Cell & Gene Therapy Manufacturing

AAV Manufacturing Using Osmolality

New Data from the Cell and Gene Therapy Catapult shows improved yield, quality, and process efficiency for AAV manufacturing using osmolality.

Stem Cell Development & Manufacturing

Beating the System with Advanced High Throughput and Real-Time Analytics for Biopharmaceutical Manufacturing

Can advanced analytical processing and real-time data monitoring conquer the complexity of Bio-pharmaceutical manufacturing? We ask Udayanath Aich, Director at Bristol Myers Squibb.

Upstream & Downstream Bioprocessing

Process Development and Manufacturing Avenues for Gene Therapy Vectors

Hemant Dhamne, Head of Process Development of Gene Therapy at King's College London, discusses the process of viral vector production, the current and future manufacturing technologies, and challenges in the field.

Cell & Gene Therapy Manufacturing

In Conversation With...Ruth Faram, HigherSteaks

Dr. Faram is co-founder and Chief Scientific Officer at HigherSteaks, where she leads the company strategy and research focus for the Stem Cell, Bioprocess, Differentiation and Biomaterial teams.

Upstream & Downstream Bioprocessing

Novel Technologies Advancing Downstream Bioprocessing

Tuhina Bhattacharya, Associate Director of CMC Biologics at Corbus Pharmaceuticals, leads a Discussion Group on the future of downstream bioprocessing technologies.

Cell Therapy Development

In Conversation With Pedro Caetano Pinto, Lab Lead in Experimental Urology, Universität Greifswald

We interview Pedro-Caetano Pinto, Lab Head at the University of Greifswald to learn more about his work with microphysiological systems for advanced kidney and prostate cancer research.

Cell Therapy Development

Q and A with Vasiliki E. Kalodimou

Vasiliki Kalodimou of the NCSR DEMOKRITOS, discusses her work in cell therapy analytics, ahead of Oxford Global's Cell Therapy Analytics Event.

Stem Cell Development & Manufacturing

Combinatorial Culture Technology for Stem Cell Therapy Applications

How can combinatorial screening of diverse variables in process development optimise cell and gene therapies? Marina Tarunina, Research Director at Plasticell, investigates.

Tissue Engineering & 3D Models

Human Stem Cell Model Development for Neurodegenerative Diseases

How can the use of human stem cell models of neurodegenerative disease advance drug discovery? Clare Jones, Chief Scientific Officer at Talisman Therapeutics, investigates.

Cell & Gene Therapy Manufacturing

In Conversation With Jenny Prange, Head of GMP Production, Chief Scientific Officer and Co-Founder of Muvon Therapeutics

The present and the future, key insights into the cell and gene therapy manufacturing space

Gene Therapy Development

Abundant Stochastic Off-Target Activity by Base Editors

Can complementary approaches for off-target quantification demonstrate substantial levels in various state-of-the-art editors?

Gene Therapy Development

When to Cut and When to Inhibit? A Low-Throughput, Hands-On Investigation Of CRISPR-Cut and CRISPRi Efficiencies In iPSC And Neural Cells

Gene knockdown – the manual reduction of a particular gene's expression in target cells – entails the modification of cellular development in young cells. CRISPR gene editing techniques enable researchers such as Pia Johansson to induce gene knockdown in target cells.

Gene Therapy Development

Overcoming the Challenges of Precision Genome Editing

Experts from academia and industry discuss the current obstacles and opportunities for genome editing during a roundtable session at Gene Therapy Development & Manufacturing: In-Person.

Tissue Engineering & 3D Models

Speaker Insights – In Conversation with Pedro-Caetano Pinto

Discover key insights into the application of microphysiological systems for advanced kidney and prostate cancer research.

Cell & Gene Therapy Manufacturing

Developing Meaningful Assays: Balancing Biological Significance and QC-Compatibility

Katrina Adlerz, Scientist at The University of Texas MD Anderson Cancer Center presents on developing meaningful biologic assays at the Cell Therapy Analytics Symposium 2022.

Cell & Gene Therapy Manufacturing

Gene Therapy Manufacturing

June's Discussion Group welcomed a panel of industry experts to debate manufacturing and standardisation challenges for the commercialisation of cell and gene therapies.

Stem Cell Development & Manufacturing

Potency Assays for ?-Thalassemia and Sickle Cell Disease Gene Therapy Drug Products

In this Commentary article, we explore how reductions in testing complexity can improve access to hematopoietic stem cell therapies for patients with blood disorders. The provision of safe, effective therapies will help to ameliorate the worst impacts of these disorders for patients and afford them a better quality of life.

Gene Therapy Development

Refining Analytics for Gene Delivery Systems

Key opinion leaders from Roche and Purespring Therapeutics debate future strategies for advancing cell and gene therapeutics.

Cell Therapy Development

A Front-End Automation Method for QIAcuity Digital PCR Plate Setup using the QIAgility Liquid Handling Instrument

Cell Therapy Development

Assessment of the Precision and Sensitivity of QIAcuity® Nanoplate Digital PCR vs. qPCR

Cell Therapy Development

Biocair: General Services

Cell & Gene Therapy Manufacturing

Biocair Case Study: Best in Class Performance

Cell Therapy Development

Biocair Case Study: Delivering Personalised Supply Chains for Autologous Cell Therapies

Cell & Gene Therapy Manufacturing

Bio-Techne: Genome Engineering Services for Cell Therapy Manufacturing

Cell & Gene Therapy Manufacturing

Bio-Techne: GMP ProDotsâ„¢ Proteins, a User Guide

Cell & Gene Therapy Manufacturing

Bio-Techne: Product Portfolio Overview

Cell & Gene Therapy Manufacturing

Bio-Techne's Ella: Your Immunoassay Problem Solver

Cell & Gene Therapy Manufacturing

Bio-Techne: Cell and Gene Therapy Manufacturing Solutions

Cell & Gene Therapy Manufacturing

Bio-Techne: Changing the Way Scientists Analyse Proteins

Gene Therapy Development

Daikyo Crystal Zenith® Case Study: Meeting the Challenge of Viral Vector Delivery

Cell Therapy Development

FUJIFILM Irvine Scientific: HEK Media Survey Panel

Cell Therapy Development

NanoView Biosciences: ExoView R200 Imaging Platform

Cell Therapy Development

NanoView Biosciences: LentiView Kit Brochure

Cell Therapy Development

NanoView Bioscience: Plate Washer Brochure

Cell Therapy Development

NanoView Biosciences: A Critical Comparison of Nanoparticle Tracking Analysis (NTA) and ExoView®

Cell Therapy Development

QIAcuity® Digital PCR System

Cell Therapy Development

rAAV Vector Genome Titer Protocol Using the QIAcuity® Digital PCR System

Cell Therapy Development

Transferring and Optimising Assays from Quantitative PCR to Digital PCR on the QIAcuity® System

Gene Therapy Development

West Pharmaceutical Solutions: Protect Your Gene Therapy Product with an Approved Container Closure System

Gene Therapy Development

West Pharmaceutical Solutions: Packaging Containment Solutions for Gene Therapy Products

Gene Therapy Development

West Pharmaceutical Solutions: Gene Therapy and Daikyo Crystal Zenith® Vials Case Study

Cell Therapy Development

Cell Therapy Analytics

Glyn Stacey, Chief Executive at SSCBio leads a discussion on the current landscape of ‘Cell Therapy Analytics'.

Upstream & Downstream Bioprocessing

Upstream Bioprocessing

Amir Reza Goudarzi, former Engineering Head of UCB in Brussels, leads a discussion on ‘Upstream Bioprocessing.'

Upstream & Downstream Bioprocessing

Future Directions for Accelerated Upstream Bioprocessing

Key opinion leaders from Novartis, Achilles Therapeutics, and AbbVie divulge their views on what's next for upstream bioprocessing.

Upstream & Downstream Bioprocessing

Digital Twins: Upstream Processing Applications and Hybrid Models

This Commentary article investigates the potential applications of digital twins in refining the developmental timeline for drug substance development. Capturing and conserving the understanding from ongoing processes allows researchers to learn more about the intricacies of the developmental process more rapidly.

Tissue Engineering & 3D Models

Understanding Disease Progression with 3D Model Development

Will 3D model development reach its potential to innovate cell and gene therapeutics? We spoke to Merck, GlaxoSmithKline, East Carolina University Brody School of Medicine, and the Institute of Molecular Biotechnology to find out more.

Tissue Engineering & 3D Models

3D Model Development

Oxford Global's Discussion Groups provide a focused networking opportunity for a handful of like-minded experts on a monthly basis. Our April Discussion Group addressing ‘3D Model Development' brought together an exclusive panel of key opinion leaders to address the market's growth and future directions.

Tissue Engineering & 3D Models

Tackling Tumours In-Vitro with 3D Cell Cultures

Raymond R. Mattingly explains the applications of 3D cell culturing at Oxford Global's 3D Cell Culture Symposium.

Cell Therapy Development

Scaling Approaches to NK Cell Production for Off-The-Shelf Delivery

This Commentary piece explores how the production and delivery of NK cells could provide a new option for clinical treatment of illnesses such as myeloid leukaemia, with the potential for scaling approaches to be incorporated into the treatment process.

Cell Line Development & Engineering

Cell Line Engineering

Oxford Global's Discussion Groups provide a focused networking opportunity for a handful of like-minded experts on a monthly basis. Our February Discussion Group addressing ‘Cell Line Engineering' was a tremendous success. The discussion brought together an exclusive panel of key opinion leaders to address the key factors behind the market's growth, its priorities, future outlook, and challenges.

Gene Therapy Development

Inciting Rapid Standardisation in Cell and Gene Therapy Manufacturing

Can the cell and gene therapy field create industry consensus on a more detailed level? In this Insight Article, Jorgen Magnus, Strategic Program Lead of Cell and Gene Therapy at Bayer, highlights the promise of process mapping for reaching a harmonised approach to development and manufacturing standards.

Cell Line Development & Engineering

Cell Line Development with Advanced Cell Line Engineering

The need to demonstrate clonality for regulatory approval means that now more than ever, the industry must look towards streamlining and optimising clone selection efficacy. We sat down with senior representatives from Ichnos Sciences and Sanofi to learn how.

Cell & Gene Therapy Manufacturing

Streamlining Stem Cell Manufacturing

Oxford Global's Discussion Groups provide a focused networking opportunity for a handful of like-minded experts on a monthly basis. Our January Discussion Group addressing ‘Streamlining Stem Cell Manufacturing' was a tremendous success. The discussion brought together an exclusive panel of key opinion leaders to address the key factors behind the market's growth, its priorities, future outlook, and challenges.

Cell Therapy Development

Advancing The Implementation Of Automation Technologies For Cell Therapy Development

Oxford Global's Discussion Groups provide a focused networking opportunity for a handful of like-minded experts on a monthly basis. Our November Discussion Group addressing ‘Advancing The Implementation Of Automation Technologies For Cell Therapy Development' was a tremendous success. The discussion brought together an exclusive panel of key opinion leaders to address the key factors behind the market's growth, its priorities, future outlook, and challenges.

Stem Cell Development & Manufacturing

Advancing Stem Cell Manufacturing

Regenerative medicine is a highly promising branch of pharmacology. With the growing demand for stem cell therapies, the need for streamlined manufacturing is more critical than ever. We sat down with senior representatives from Procella Therapeutics, the University of Reading, and Newcastle University to learn more about the future of stem cell production.

Stem Cell Development & Manufacturing

Three Studies in 3D Stem Cell Culture

Dr Darius Widera shows us three case studies on 3D stem cell cultivation using fibrin, nanofibrillar cellulose, and hybrid scaffolds

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