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Spatial Biology | Webinars

A Spatial Examination of The Brain - From Development To Disease At The Subcellular Level

09 May 2022
Rebus Biosystems has assembled five collaborators to share aspects of their cellular examinations of the human brain. From new strides in understanding brain development to exploring the sub cellular details of disease, these presentations illustrate the array of knowledge gained through cellular spatial exploration.
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Presentation One:
Disease-associated Oligodendrocyte Responses Across Neurodegenerative Diseases
Shristi Pandey, Scientist, Computational Biology at Genentech

Presentation Two:
An Atlas of Cortical Arealization Identifies Dynamic Molecular Signatures
Aparna Bhaduri, PhD, Assistant Professor, UCLA

Presentation Three:
Scalable In Situ Single-Cell Profiling by Electrophoretic Capture of mRNA
Sten Linnarsson, Professor of Molecular Systems Biology, Karolinska Institute

Presentation Four:
Spatiotemporal Analysis of Microglia in the Developing Human Brain
Galina Popova, PhD. Postdoctoral fellow, University of California, San Francisco

Presentation Five:
Decoding the Human Brain’s Vasculature and Arteriovenous Malformations
Ethan A. Winkler, MD, PhD, Fellow in Endovascular, Surgical Neuroradiology, Barrow Neurological Institute, Research Associate, Weill Institute of Neuroscience, University of California San Francisco

https://www.youtube.com/watch?v=LH5aUzHlQ6g
Watch the full webinar

Speaker Biographies

Shristi Pandey, Scientist, Computational Biology at Genentech
Shristi Pandey is a scientist in the Department of Bioinformatics and Computational Biology at Genentech, where she combines genetics, transcriptomics, proteomics and imaging data to identify and inform novel therapeutic targets and biomarkers for neurodegenerative diseases. She obtained a B.S. in Molecular and Cellular Biology from Stanford University and earned her PhD. in Molecular and Cellular Biology from Harvard University.

Aparna Bhaduri, PhD, Assistant Professor, UCLA

Dr. Aparna Bhaduri earned a B.S in Biochemistry and Cell Biology and a B.A in Political Science from Rice University in 2010. She completed her doctoral studies at Stanford University in Cancer Biology in 2016, where she focused on epithelial tissue differentiation and neoplasms She was a postdoctoral scholar at the University of California San Francisco in the lab of Dr. Arnold Kriegstein. As a postdoctoral scholar, she used single-cell RNA sequencing to characterize cell types in the developing cortex across cortical areas, in human and non-human primates, and in glioblastoma. Because experimental manipulations of the developing human cortex will require in vitro models, she has been using similar approaches to compare cells types in organoid models and primary tissues. Her long term interests to be pursued in her own independent laboratory at UCLA are in understanding how stem cells during cortical development give rise to the human brain, and how aspects of these developmental programs can be hijacked in cancers such as glioblastoma.

Galina Popova, PhD. Postdoctoral fellow, University of California, San Francisco

Galina Popova received her PhD in biomedical sciences at University of California, Irvine. She is now a postdoctoral scholar at University of California, San Francisco, where she studies microglial biology and neuro-immune interactions. Her work investigates how different microglia subtypes are established and maintained during normal brain development and neurodevelopmental disorders.

Ethan A. Winkler, MD, PhD, Fellow in Endovascular, Surgical Neuroradiology, Barrow Neurological Institute, Research Associate, Weill Institute of Neuroscience, University of California San Francisco

Ethan Winkler, MD, PhD, is a neurosurgeon-scientist who specializes in the endovascular and microsurgical treatment of cerebrovascular disorders. He completed both an MD and PhD at the University of Rochester School of Medicine and Dentistry. His graduate thesis work investigated vascular contributions to neurodegenerative diseases, such as Alzheimer's Disease and amyotrophic lateral sclerosis, with an emphasis on defining the function of brain pericytes. He subsequently completed both neurosurgical residency training and post-doctoral fellowships at the University of California San Francisco. He is currently a fellow in Endovascular Surgical Neuroradiology at Barrow Neurological Institute and Research Associate in the UCSF Weill Institute of Neuroscience.  He is interested in leveraging his unique access to the human brain to investigate cellular contributions to cerebrovascular diseases with special focus on arteriovenous malformations. It is his long-term goal to develop highly effective and safe translational therapies to fill in vital gaps in available treatment modalities and improve outcomes in patients with vascular malformations.

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