Giacomo Cavalli studied Biology at the University of Parma and did his PhD at the Swiss Federal Institute of Technology (ETH) in Zurich. After a postdoc with Renato Paro in Heidelberg, he set up his lab at the IGH in 1999 and has stayed there since. Using Drosophila melanogaster and mouse ES cells as models, he has made seminal contributions in areas such as epigenetic inheritance and chromatin structure and its role in gene regulation. He discovered transgenerational epigenetic inheritance, Topologically Associating Domains (TADs) and showed tumor suppression activity of PcG proteins in flies. He has received numerous awards and distinctions, has organized major international conferences and is member of several distinguished scientific boards.