Rapid Analytical Approach for Biologics Characterization Using Mass Photometry
The technological advancements are enabling the characterization of antibody and viral vector samples to be faster, easier to perform and requires less sample than the conventional bioanalytical methods.
This on-demand video discusses mass photometry and provides insight into the capabilities of the technology for characterization of therapeutic antibody samples. Case studies showcase the assessment of stoichiometries in antibody-antigen interactions, Kd calculation, as well critical quality attributes such as degradation and aggregation. Additionally, we will demonstrate how the data obtained through mass photometry compares to and complements the current gold standard for antibody aggregation, size exclusion chromatography (SEC-UV).
Updates also include the expanding portfolio of consumables and instrument add-ons. You will learn about MassFluidix HC, a microfluidic system which expands the concentration range amenable to mass photometry analysis to micromolar range. This new add-on offers rare insight into how proteins behave at high concentrations, hence allowing to study low affinity interactions.
Key Learning Outcomes:- Benefits of mass photometry for characterization antibody samples
- How mass photometry compares to size-exclusion chromatography and other orthogonal methods
- Innovations in mass photometry analysis and gaining insight into low-affinity interactions
