Dr. Stefan Hauser is Head of a Stem Cell Laboratory at the German Center for Neurodegenerative Diseases (DZNE) in the Department of Clinical Neurogenetics. He received a Graduate engineer (Dipl.-Ing.) in Biotechnology from Bingen University of Applied Sciences (2008), a M.Sc. in Molecular Cell Biology from Bielefeld University (2010) and holds a Ph.D. in Neurobiology (2013). He has been working at the German Center for Neurodegenerative Diseases since 2013. He is leading a Stem Cell Laboratory to investigate rare monogenetic neurological disorders with a focus on hereditary spastic paraplegia (HSP) by the use of induced pluripotent stem cells (iPSCs). For this purpose, he successfully developed and implemented methods like the generation of integration-free iPSCs from fibroblasts and PBMCs, genetic modifications using CRISPR/Cas9 as well as the differentiation of iPSCs into cortical neurons. Additionally, he uses mouse models of HSP to study preclinical treatment strategies in vivo.