Elizabeth De Lange

Professor Predictive Pharmacology
LACDR - Division of Systems Biomedicine and Pharmacology
Nina E. Weisser
Elizabeth (Liesbeth) de Lange is Professor of Predictive pharmacology at the Leiden Academic Centre for Drug Research (LACDR). She is head of the research group Predictive Pharmacology and mainly aims at developing mathematical models that can predict the effect of drugs in human. Her research program focusses on the development of generally applicable pharmacokinetic (PK)-pharmacodynamic (PD) models that distinguish between drug and body properties using advanced in vivo animal models and mathematical modelling techniques. A recent success is the development of a physiologically-based CNS PK model that is able to prediction of drug distribution into and within the human CNS (Yamamoto et al, Eur J Pharm Sci, 2018). With this model, she is able to recognize promising drug candidates in an early phase of drug development, by predicting which molecules could reach the desired concentrations in the brain. This will also reduce the use of animals in experiments substantially. A second application is that it helps to improve the design of clinical research in an early phase. Another highlight is the understanding the in vivo context of drug target residence time to predict the effects of drugs (De Witte et al, Nat Rev Drug Discov, 2018)


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