In-Depth

The In-Depth page consists of Insight Articles, Commentaries, C-level Q&As, Discussion Group Reports, and Survey Reports.

Commentary
In this Commentary article, we explore the opportunity afforded by Sparsely Connected Autoencoders to transform data in a controlled way to enable the comprehension of hidden biological information in single-cell data. Autoencoders provide researchers with a simplified means of inspecting functional relationships among regulatory elements as transcription factors.
28 July 2022
Single Cell Analysis
Insight Article
This Insight article explores some of the key applications of mass spectrometry imaging across the medical and pharmaceutical landscape. With the field seeing constant rapid development, mass spectrometry is an essential tool for current and future research in healthcare.
Edited by Ben Norris |
25 July 2022
Spatial Biology
Insight Article
Long Read DNA Sequencing has the potential to help diagnose several diseases and disorders. Recent advancements mean that long-read sequencing is no longer an expensive, low throughput, error-prone process.
Edited by Oliver Picken |
22 June 2022
Genome Editing
Insight Article
In this Insight article, we explore some of the challenges and new innovations concerning spatial analysis of the tumour microenvironment. One of the key focuses for ongoing studies is the retention of spatial information, which enables researchers to identify distinct tumour subtypes.
Edited by Ben Norris |
21 June 2022
Spatial Biology
Discussion Group Report
In this Discussion Group Report, we investigate some recent applications of long- and short-read sequencing technologies. Continued improvements and advancements in the field mean sequencing errors are increasingly a thing of the past, while the portability of some new units makes them ideal for work in the field.
Edited by Ben Norris |
14 June 2022
NGS & Clinical Diagnostics
Discussion Group Report
Our November 2021 Discovery Series discussion group focused on the current uses and potential of multi-omics bioinformatics.
Edited by Oliver Picken |
27 May 2022
NGS & Clinical Diagnostics
Discussion Group Report
Our April 2022 Omics Series discussion group focused on the potential and future of single-cell proteomics.
Edited by Oliver Picken |
25 May 2022
Single Cell Analysis
Commentary
In this Commentary article, we investigate the application of new research techniques to inspecting genomic data for the presence of de novo variants - genetic alterations present for the first time in one individual as a result of a variant inherited from a parent. Used in combination with data from the 100,000 Genome Project, these techniques could reduce the time taken for patients to receive a diagnosis for rare genetic diseases.
Edited by Ben Norris |
16 May 2022
NGS & Clinical Diagnostics
Discussion Group Report
This month’s discussion was led by Pieter van der Velden. Topics included improving multiplex assays, T-Cell quantification and DNA methylation.
Edited by Oliver Picken |
05 May 2022
Digital PCR
Insight Article
Single-cell proteomics has developed quickly, despite being a relatively new field. NanoPOTS and FACS are being used to improve proteome coverage and minimise sample size.
Edited by Oliver Picken |
05 May 2022
Single Cell Analysis
Commentary
At NGO US: In-Person 2022, Carlos Cruchaga of the Washington School of Medicine presents on using QTL and GWAS data to unlock the future of therapeutic treatment for neurodegenerative disease.
Edited by Tia Byer |
30 April 2022
NGS & Clinical Diagnostics
Insight Article
Explore the history of PCR and how digital droplet PCR is being used for COVID-19 research.
Edited by Oliver Picken |
25 April 2022
Digital PCR
Insight Article
With the development of single-cell RNA sequencing, it became possible to measure transcriptomes at a single-cell resolution. Is spatial transcriptomics the next step on the journey of understanding human biology?
Edited by Oliver Picken |
21 April 2022
Spatial Biology
Discussion Group Report
Our February discussion group bought together more than 40 key opinion leaders to debate the future of spatial biology. Spatial transcriptomics, single cell resolution and tissue preparation were among the key topics raised.
Edited by Oliver Picken |
17 March 2022
Spatial Biology
Discussion Group Report
Our February Omics discussion group focused on novel genome editing and how new technologies are being used to tackle the challenges of transitioning to therapeutic use.
Edited by Oliver Picken |
11 March 2022
Genome Editing
Commentary
In this commentary article, we present Dr Valerie Taly’s insights on the latest research into digital droplet PCR and the potential applications of liquid biopsy in cancer detection.
Edited by Ben Norris |
11 March 2022
Digital PCR
Insight Article
Due to the heterogeneity seen in both eukaryotic and prokaryotic cell populations, single cell analysis opens up many new possibilities.
Edited by Oliver Picken |
14 February 2022
Single Cell Analysis
Insight Article
Spatial omics is changing how we think about biology, giving us an unprecedented view into single cells and tissues.
Edited by Oliver Picken |
09 February 2022
Spatial Biology
Commentary
When gene therapy goes wrong, it can have severe consequences. Dr Giandomenico Turchiano tells us how he can use ddPCR to catch those mistakes
Edited by Tom Cohen |
31 January 2022
Gene Therapy Development
Commentary
The applications of NGS are swiftly expanding, and new methods for data storage, analysis, and visualisation are needed. However, the complexity of sample processing for NGS has created problems in managing, analysing, and storing the datasets. 
Edited by Oliver Picken |
03 November 2021
NGS & Clinical Diagnostics

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