Constance Vennin is a research scientist in Pr Beat Lutz’s group at the Deutsches Resilienz Zentrum (DRZ) gGmbH in Mainz, Germany. During her PhD, in France, she deciphered mechanisms of non-coding RNA in breast tumor. However, she was facing the issue of tumor heterogeneity. So, she decided to learn more about the power of single-cell analysis. Therefore, she moved to her current position. By using single-cell RNA-seq in the mouse model, she is identifying neuronal subpopulations and transcriptional network involved in resilience and non-resilient behavior. She is not only revealing distinct neuronal subpopulations but also uncovering how these subpopulations behave differently in resilient and non-resilient animals in response to chronic social defeat stress.