Bart Westendorp's primary research interest is to understand how decision-making is done in cells during normal cell division, cell stress, development, and regeneration. His team combines live cell microscopy with single cell next-generation sequencing to address this topic. Their work aims to unravel at single cell resolution how cancer cells can adapt to DNA replication stress, and how these adaptations can be linked to resistance against anti-cancer drugs.
In 2015, Bart Westendorp has initiated the Single Cell Analysis Center, a research facility for the genomic and transcriptomic analysis of single cells. Their cell capturing platforms - a VyCAP single cell puncher and a Leica LMD7 laser microdissection microscope customized for live cell imaging – make it possible to combine genomic and microscopy data from the same cells. This facility supports researchers with imaging and capturing of single cells for next generation sequencing, as well as with the downstream bioinformatics analysis.