Amin Allahyar

Postdoc, Developmental Biology and Stem Cell Research
Hubrecht Institute

Amin Allahyar got his BSc. in computer engineering and software development from Bahonar University of Technology, Shiraz, Iran in 2010. Later in 2012, he received his (cum laude) MSc. focusing on artificial intelligence and pattern recognition from Ferdowsi University of Mashhad, Iran. He moved to the Netherlands to the Delft University of Technology and worked with Dr. Jeroen de Ridder where he investigated the relationship between genome wide gene expression profiles of breast cancer patients and patient’s survival after chemotherapy treatment (2018). He is currently doing a Postdoc under supervision of Prof. Wouter de Laat. In particular, their focus is on exploiting the long-read sequencing platforms such as PacBio and Nanopore sequencing technologies to investigate interactions that co-occur between multiple regulatory elements at the same time within the local 3D neighborhood of the nucleus. Using such methods, they already demonstrated how multiple enhancers can simultaneously interact with multiple genes and also uncovered how multiple CTCF sites can form entangled loops resulting in a phenomenon called a “traffic jam” (Allahyar et al. 2018). Their contributions demonstrate the principles and functional significance of long-range DNA contacts as a regulatory element in the genome.

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