Tumour associated macrophages are critical drivers in cancer progression and metastasis. Clinical studies now suggest that changing polarisation of macrophages can significantly improve immuno-oncology response. Speaking with senior representatives from Verseau Therapeutics, Pathios Therapeutics, and Faron Pharmaceuticals, we delve into some of the latest techniques in macrophage targeting.

The activation of GPR65 on immune cells by the acidic tumour microenvironment and the resultant immunosuppression may be one of the principal reasons many cancers do not respond to current T Cell checkpoint therapies. Chief Executive Officer Stuart Hughes delves into some of Pathios Therapeutics recent developments in macrophage conditioning and its promise to enable a successful anti-tumour immune response.

At the 2021 Immuno Week: Online event, we sat down with an advisory board comprised of key figures from some of the top biotech companies and research institutions to discuss the acute need for improved combination therapies and predictive biomarkers in immuno-oncology.

Patient-specific medicine in Immunotherapy and Immuno-oncology is fast becoming a globally recognised form of cancer treatment. But how easy is it to apply AI and ML to tailor a treatment for each individual patient? Director of Genomic Immuno-Oncology at Evaxion Biotech, Jens Kringelum, investigates how best to integrate data generation and ML to decode the immune system.