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Advancements in Spatial Genomics Research- Oncology focus

Thursday 29th October 2020 | 15:00 - 16:00 GMT

Register for the webinar that includes three short presentations on Spatial Biology and one narrated poster. The illustrious presenters will share interesting insights on how to uncover biomarkers in situ and how to deconvolute scRNA data and spatial profiling results in situ.

Presentations Include:

Introduction | Agnese Winfield, PhD, Marketing Dir. NanoString
The 2 minutes introduction will be followed by:

Spatial Characterization of The Tumor-Immune Microenvironment Through Therapy in Breast Cancer | Christina Curtis, PhD, Associate Professor, Medicine – Oncology- Stanford University

The work presented is addressing the critical need to identify biomarkers of treatment response in early stage HER2-positive breast cancers. The Stanford team used NanoString’s GeoMx™ Digital Spatial Profiler (DSP) to quantify 38 tumor and immune proteins across multiple panCK-enriched regions from HER2-positive breast cancers, after different treatments, Important biological insights into the role of innate immune markers, ER status, and pam50 subtype on treatment response are presented.

Spatial Transcriptomics and Single-Cell Integration for In-Depth Localized Tissue Interrogation | Ioannis Vlachos, PhD, Assistant Professor of Pathology, Beth Israel Deaconess Medical Center

The talk will cover the method to integrate spatial information with single nucleus sequencing. The biology is focused on the characterization of lung tissue samples from COVID patients. The work carried out with the Whole Transcriptome Assay, on GeoMx DSP, to elucidate the genes and functional pathways associated immune response, and tissue damage and repair.

Highly Multiplexed Digital Spatial Profiling of the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma Patients Treated with Immune Checkpoint Therapy | Arutha Kulasinghe. PhD. NHMRC Research Fellow, Queensland University of Technology

In this study, the GemoMx™ Digital Spatial Profiler (DSP) was used to determine the immune markers and compartment specific measurements in a cohort of HNSCC tumours from patients receiving Immune checkpoint therapy.

Updating immune cell deconvolution for the spatial genomics era | Patrick Danaher, PhD Principle Statistician NanoString

The final part of the webinar is a poster presentation- Dr Patrick Danhart will share in less than 5 mins the deconvolution methodology for the integration of scRNASeq data in the tissue spatial context.

If you would like to receive copy of this poster, please contact awinfield@nanostring.com

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