Advanced Instruments has developed a portfolio of osmometers that can support workflow optimization in cell and gene therapy, designed specifically to fit your bioprocess. Our osmometers provide accurate and precise measurements with robust data integrity and connectivity features that ease compliance to regulations including 21 CFR Part 11, EU Annex 11 and make for easy incorporation into a GMP environment. The OsmoTECH®XT Single-Sample Micro-Osmometer is designed for viscous, complex samples such as cryo-preservatives and highly concentrated biomolecules. The OsmoTECH® PRO Multi-Sample Micro-Osmometer is suited to higher throughput cell culture development applications. They can evolve with the changing needs of your organization with their highly configurable settings, unparalleled operational efficiency, and robust data integrity features. Data has consistently shown that medium osmolality plays an important role in gene therapy development in general and in viral vector manufacturing in particular. Recently launched data from the UK Cell and Gene Therapy Catapult shows that yield, quality and process efficiency for AAVs are all significantly improved by controlling and optimizing osmolality within process development. The scientific literature has long shown that osmolality is a factor in viral vector stability and aggregation for retro viruses generally and lentivirus in particular and several studies show that optimizing osmolality has beneficial effects on stem cell culturing processes.