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The latest in drug discovery, from novel targets and screening tools through to automation and computational chemistry

Top R&D Stories of 2023

Through captivating articles, insight pieces, and spotlight interviews, we delve into the remarkable innovations, breakthroughs, and scientific marvels that have defined the landscape of research over the past year.
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Neuroscience Discovery

Beyond Traditional Therapeutics: How Digital Therapeutics Reshape Neurological and Neuropsychiatric Treatments

Two case studies show how digital therapeutics can potentially treat neurological and neuropsychiatric conditions, areas where conventional therapeutics have encountered obstacles.
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Neuroscience Discovery

University of Pennsylvania and FAST to Develop AAV Gene Therapy for Angelman Syndrome

The collaboration hopes to develop a AAV gene therapy for rare genetic disease Angelman syndrome.
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Neuroscience Discovery

Neural Stem Cell Workflow Solutions

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Neuroscience Discovery

Challenges in Developing Organoids for Neuroscience

Oxford Global’s panel discussion: Translational Models from 3D to Animal Model of Disease – Neuroscience, asked experts to share their experience of developing organoids for translational neuroscience.
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Neuroscience Discovery

Prothena and Evotec Score Major Deals with Bristol Myers Squibb for Neuroscience Breakthroughs

Prothena will receive $55 million to license its clinical Alzheimer's drug candidate, while Evotec will receive $40 million for its late-stage clinical programs.
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Neuroscience Discovery

Investigating Target Identification and Validation Modelling in Neurodegenerative Disease

The significance of reproducibility, fidelity, and translatability in models, as well as the importance of using multiple models to cross-validate therapeutic targets.
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Neuroscience Discovery

Nasal Spray Shows Remarkable Efficacy in Easing Social Anxiety: Vistagen's Fasedienol Promises New Hope

Positive phase III results propel innovative pherine nasal spray as potential game-changer for millions struggling with social anxiety disorder. Vistagen's novel mechanism of action sparks optimism after previous setback.
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Neuroscience Discovery

Interview with Nicolas Vachicouras, CEO, Neurosoft Bioelectronics: Subdural Brain Interfaces

Talking with Nicolas Vachicouras, CEO of Neurosoft Bioelectronics about their subdural brain interface and its inaugural clinical testing for recording the human brain in the context of an epilepsy resective surgery.
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Neuroscience Discovery

Interview with Valentina Mosienko, Fellow and Lecturer in Neuroscience, University of Bristol

Navigating the neuroscientific pathways for anxiety towards druggable targets.
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Neuroscience Discovery

Gene Discovered to Drive Anxiety Could Prove an Effective Drug Target

The discovery could be a game-changer for the many people that suffer from anxiety related mental health disorders.
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Neuroscience Discovery

Positive Results Achieved from Phase III Trial of MDMA-Assisted Therapy

Significant findings after the Schedule I controlled drug completes Phase III clinical trial for PTSD patients.
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Neuroscience Discovery

Discovery of Fentanyl Vaccine Called “Game Changer” with Some Sceptical

The antibody-based vaccine has been successful in rat models but has had critics who would rather see a focus on harm reduction.
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Neuroscience Discovery

Alzheimer’s Drug Lecanemab Slows Cognitive Decline at Cost of Side-Effects, Shows Clinical Trial

Eisai and Biogen have shared the data from a phase III trial of their joint effort Alzheimer’s drug, lecanemab
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Neuroscience Discovery

Small Molecule Targets Toxic RNA Linked to ALS and Dementia

A UF Scripps Biomedical Research team have developed an RNA-targeting blood-brain penetrant small molecule to tackle genetic cases of ALS and dementia.
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Neuroscience Discovery

Spatial RNA and Protein Detection Automated on Roche Discovery Ultra Platform

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Neuroscience Discovery

New Study Includes Pain Management Device for Chronic Symptoms of NFL Players

The study will focus on non-invasive vagus nerve stimulation (nVNS) and cannabidiol (CBD) as potential treatments.
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Neuroscience Discovery

Tocris Fluorescent Probes and Dyes

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Neuroscience Discovery

Delix Therapeutics Announces 2 Partners in Neuroscience Drug Discovery Effort

The neuroscience discovery company alter the molecular chemistry of existing psychedelic drugs to maintain their psychoplastogenic properties but remove their hallucinogenic effects.
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Neuroscience Discovery

Up-and-Coming Investigations in Drug Discovery and Development: Neuroscience and AI

Drug discovery experts join Oxford Global’s Neuroscience Drug Discovery and Development discussion group.
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Neuroscience Discovery

Light Powered Neural Propagation Assay

Synaptic connections are a fundamental building block of neuronal function, enabling the propagation of activity from one neuronal circuit to another
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Neuroscience Discovery

Challenges in Translational Approaches and Biomarkers in Neurodegeneration

Identifying disease targets, understanding complex biology, and developing effective technologies for target engagement.
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Neuroscience Discovery

Axion: Neural Activity Assay

In vitro neural models are a proven powerful strategy for the study of neural function and complex disorders of the human nervous system.
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Neuroscience Discovery

Validation of a Structure-Function Assay for Neurotoxicity in Primary and hiPSC-Derived Neurons

Comprehensive, high-throughput, in vitro screening of the neurological effects of chemical compounds and drugs is vital for environmental and drug safety
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Neuroscience Discovery

Improved Insight on the Effects of Ritalin on Patients with ADHD

A better understanding of ADHD drug methylphenidate's mechanism of action has been revealed by a study published in the journal Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.
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Neuroscience Discovery

How MSD’s Discovery Centre is Fighting Age-Related Neurodegeneration

How does the MSD group find its targets for neuroscience drugs?
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