To view the complete agenda and full line up of speakers & their presentations please download the agenda to your right.

Oxford Global is proud to present for the 8^th year our flagship Cell Culture & Bioprocessing Congress. With an industry push towards technological innovation and greater efficiency across cell line development and bioprocessing, an updated 2019 programme will feature over 45 presentations on the current techniques and strategies being implemented in the drug development and manufacturing pipeline.

Through our Cell Line Development & Engineering streams, gain insights into recent CHO and protein expression strategies, stability in cell mammalian lines, establishing clonality and high throughput analytics. Reflecting current industry priorities, we are also pleased to introduce two featured sessions within the cell line engineering themes. With a global push towards more 3D cell technologies, motivated in part by a need for models that accurately resemble original tissue, we have a dedicated session on 3D cell culture techniques – predominantly scaffolding, hydrogels and spheroids – as well as the applications of these methodologies. Our second featured session looks at genomic approaches to cell line engineering, given the increasing development and use of these methods to improve efficiency and remove bottlenecks in cell line development.

The event also provides a valuable opportunity to learn about the latest technologies in bioprocessing. On Day 1, learn more about Upstream Bioprocessing, from process spectroscopy to scale-up using 3D technologies. With industry increasingly looking towards single-use systems and disposables, we have increased focus on the application of these technologies, including bioreactors. Day 2 then looks in depth at recent updates in Downstream Processing. With ever-improving instrumentation still a key priority in this area, benefit from case studies on continuous chromatography and mass spectrometry, alongside discussion of challenges in biologics manufacturing and next generation therapeutics.

Finally, new for 2019 we are pleased to announce an additional stream on Cell Banking, reflecting the importance of cell banks for the creation and storage of viable cell lines. Case studies consider the role of cell banking for complex manufacturing, the development of standardised, scalable processes and cellular harvesting strategies, as well as automation methods and cryopreservation.

These topics have been compiled as a result of a comprehensive research process undertaken with an expert panel of advisory board members from global pharmaceutical organisations, innovative biotechnology firms and leading academic research institutions.

The 8th Annual Cell Culture & Bioprocessing Congress Agenda: 

Day 1 Stream 1: Cell Line Development & Engineering

• CHO, Stem Cell and protein expression strategies for cell line engineering
• Emerging cell culture technologies and applications
• Clone selection strategies and establishing clonality
• Single cell technologies for cell culture
• Improving stability of mammalian and bacterial cell lines
• Ensuring high yield cell lines: tools and technologies
• High throughput analytics
• Applications of ‘omics technologies in cell line development

Day 2 Stream 1 Part 1: Genomic Approaches to Cell Line Development

• Gene editing tools and CRISPR systems to improve CHO phenotyping
• MicroRNAs for cell line development
• Genetic cell line characterisation

Day 2 Stream 1 Part 2: 3D Cell Culture Models & Applications

• 3D Cell Culture applications, technologies and innovations
• 3D bioprinting and microfluidics
• Applications of 3D models in clinic and industry
• Case studies into multi-organ-chip technologies
• 3D automation

Day 1 Stream 2: Upstream Bioprocessing & Analytics

• Upstream process spectroscopy
• Process scale-up including 3D technologies
• Fed batch vs. novel continuous manufacturing tools and techniques
• Integrated continuous processing methods
• High throughput technologies in bioprocessing
• Single use technologies, including:
  • Bioreactors
  • Disposable sensors
  • Cell factories

Day 2 Stream 2: Downstream Bioprocessing

• Key hurdles in the manufacture of biologics
• Case studies in monoclonal antibodies and alternative proteins
• Manufacturing and logistics of next generation therapeutics
• Continuous chromatography: bioprocessing case studies
• Improvements in instrumentation, including mass spectrometry
• Managing complex technology transfers
• Improving yield for commercial production
• Novel large-scale production tools and technologies
• Overcoming PAT and QbD challenges

Day 1 Stream 3: Cell Banking

• GMP-compliant cell banking and overcoming challenges in complex manufacturing issues
• Process scale-up strategies
• Cellular harvesting strategies
• Case studies from EBiSCand IMI
• Ensuring sample identification and high sample quality
• Developing standardized, scalable processes
• Creating IT infrastructure
• Automation methods for iPScell culture
• Best practice in cryopreservation