To view the complete agenda and full line up of speakers & their presentations please download the agenda to your right.

Oxford Global is proud to present our highly-anticipated 7^th Annual Cell Culture & Bioprocessing Congress. Following a comprehensive research process undertaken with an expert panel of advisory board members from global pharmaceutical organisations and leading academic research institutions, an updated 2018 programme ensures you will benefit from talks on the latest trends and technologies impacting growth in the cell market.

Across the two days, senior experts will showcase novel strategies currently being utilised to improve efficiency in cell line development and engineering. Case studies provide insights from leading companies into CHO and protein expression strategies, stability in cell mammalian lines and high throughput analytics.

There has been a global push towards more 3D cell technologies, motivated in part by the development of automated large-scale cell culture systems, increased focus on regenerative medicine and a need for models that accurately resemble original tissue to predict clinical outcome. New for 2018, further sessions drill more specifically into 3D cellular innovations to provide insights into disease models, bioprinting and microfluidics.

Finally, our popular bioprocessing streams have been revamped for 2018 to ensure discussion on the latest technologies affecting this area. On Day 1, learn more about Upstream Bioprocessing, from process spectroscopy to scale-up using 3D technologies. Reflecting the industry push towards single-use systems and disposables, we have increased focus on the application of these technologies, including bioreactors. Day 2 then looks in depth at recent updates in Downstream Processing. With ever-improving instrumentation still a key priority in this area, benefit from case studies on continuous chromatography and mass spectrometry, alongside discussion of challenges in biologics manufacturing and next generation therapeutics.

Day 1 Stream 1: Cell Line Development

Part 1: Early Cell Culture & Cell Line Engineering

• CHO, Stem Cell and protein expression strategies for cell line engineering
• Emerging cell culture technologies and applications
• Clone selection strategies & establishing clonality
• Single cell technologies for cell culture
• Genomic approaches:
  • Gene editing tools and CRISPR systems to improve CHO phenotyping
  • MicroRNAs for cell line development

Part 2: 3D Cell Culture Models & Applications

• 3D Cell Culture Applications, technologies and innovations
• 3D bioprinting and microfluidics
• Applications of 3D models in clinic and industry
• Case studies into multi-organ-chip technologies
• 3D automation

Day 2 Stream 1: Cell Line Development – Late Stage Cell Line Development, Stability, Data & Assay Data Development

• Improving stability of cell mammalian & bacterial cell lines
• Ensuring high yield cell lines: tools & technologies
• Genetic cell line characterisation
• Targeted sequencing for recombinant CHO cell lines
• Expression screening
• Strategies of novel bispecific antibodies
• High throughput analytics
• Applications of ‘omics technologies in cell line development

Day 1 Stream 2: Process Development – Upstream Bioprocessing and Analytics

• Upstream process spectroscopy
• Process scale-up including 3D technologies
• Fed batch vs. novel continuous manufacturing tools and techniques
• Integrated continuous processing methods
• High throughput technologies in bioprocessing
• Single use technologies, including
  • Bioreactors
  • Disposable sensors
  • Cell factories

Day 2 Stream 2: Cell Culture and Downstream Bioprocessing

• Key hurdles in the manufacture of biologics
• Case studies in monoclonal antibodies and alternative proteins
• Manufacture and logistics of next generation therapeutics
• Continuous chromatography: bioprocessing case studies
• Improvements in Instrumentation, including Mass Spectrometry
• Managing complex technology transfers
• Improving yield for commercial production
• Novel large-scale production tools & technologies
• Overcoming PAT & QbD challenges