Srinjan completed his PhD with Prof Sunney Xie and Prof Tom Maniatis at Harvard University in 2012 and his Postdoctoral Research Associate position with Prof Ernest Laue at the University of Cambridge in 2019. He has recently become a Group Leader at the Wellcome-MRC Cambridge Stem Cell Institute.
Srinjan implements biophysical and computational methods to study the architecture of the genome at the level of a single mammalian cell. For example, he has implemented single-cell Hi-C to determine how the genome folds inside individual mouse pluripotent stem cells. He has also used live cell 3D single-molecule imaging to explore how chromatin-binding proteins interact with enhancers and promoters. In particular, he is using these approaches to investigate how transcription factors and chromatin regulators influence the folding of the genome as pluripotent stem cells differentiate.