Richard Harbottle

Head of DNA Vector Research
German Cancer Research Centre (DKFZ)
Philipp Nold
Richard Harbottle is currently the Group Leader of the DNA Vector Research Group at the German Cancer Research Centre (DKFZ) in Heidelberg. Richard undertook his undergraduate studies at St Andrews in Scotland where he obtained his Honours degree in biochemistry. He then joined Imperial College London in 1991 at St Marys Hospital Medical School in Professor Bob Williamsons Department of Biochemistry where he obtained his MSc. and PhD in the Gene Therapy Research Group of Professor Charles Coutelle. Richard eventually took over the role of group leader in 2007 before moving to the DKFZ in 2013. The DNA Vector Lab has focused recently on developing a next-generation non-viral DNA vector for gene and cell therapy. This platform provides persistent expression and episomal maintenance without the use of potentially toxic viral components or the risk of insertional mutagenesis. The lab has demonstrated its utility in a range of applications in vitro, ex vivo and in vivo. This novel DNA vector platform allows the design of clinically DNA vectors that can be used to confer sustained expression of corrective genes and can be compared in application to established integrating vector and gene editing systems.

Sessions

October 29 2019, 17:50
 - 18:20
A Novel, Non-Integrative DNA Nanovector System For The Modifi cation And Manufacture Of CAR-T Cells