Nick Leslie

Director of Research, School of Engineering and Physical Sciences
Heriot Watt University
Philipp Nold
Nick studied Genetics at Cambridge and Glasgow Universities before in research at the Beatson Institute and the University of Dundee he began work addressing cellular control mechanisms which are disturbed in many cancers. Specifically, Nick has worked extensively on the tumour suppressor protein PTEN, the function of which is disrupted in around a third of all cancers. Nick and his lab were the first to show regulation of cellular PI3K signalling via PTEN oxidation, which now serves as a paradigm for the regulation of protein function by reversible oxidation. They also cloned and characterised the closest relative to PTEN in the human genome, the voltage regulated phosphatase TPIP/TPTE2. Notably, the NRL lab used 3D cell cultures to develop more relevant models to study cell signalling, showing that 3D glioblastoma cultures had gene expression signatures and gave functional data both far closer to human clinical data than previous culture-based alternatives. This motivated the bioengineering collaborations which he is now engaged in to develop biofabrication and 3D bioprinting methods to provide improved cancer models. In 2013, Nick moved his laboratory to Heriot Watt University, where much of his research now involves collaborations with engineers and physicists, applying these new technologies to cancer research. His 90+ publications currently accumulate over 400 citations per year.


October 30 2019, 17:00
 - 17:30
Novel Method Development In 3D Bioprinting