Nicolas studied biochemistry at the Diderot University of Paris where he received his Ph.D. working on the protein degradation machinery. Then he spent more than 15 years on several drug discovery projects for oncology and immune disorders in industry and academic laboratories. He first joined the Center for Protein Engineering in Cambridge (United Kingdom) to work on transcription factor and stayed at the Laboratory of Molecular Biology in Cambridge to work on ribosome biology and their defects in bone marrow syndrome. Nicolas then moved to UCB Celltech near London to lead small molecule programs for Protein-Protein Interactions target. He eventually joined Sanofi and continued to work on challenging targets. Using new modalities, Nicolas has developed a deep understanding of molecular mechanisms in immunology.