: Pre-Event Webinars

Pre-Event Webinars

26 - 28 April 2021 | BST (UTC+1)

Presented by expert speakers from leading pharmaceutical companies, these workshops will give you advanced insights into topic areas that the event will address

Can’t make the date? Still register to receive the recording afterwards.

High Purity Peptide Synthesis Capable of Achieving Efficient Milligram to Kilogram Scale with cGMP Methodology

Thursday 06 May 2021 | 13:00 BST (UTC+1) | 09:00 ET

Presentation Overview

The use of high efficiency solid phase peptide synthesis (HE-SPPS) allows synthesis of peptides at a previously unprecedented level of high speed, high purity, and low production of chemical waste. These developments allow the production of a difficult 10 mer peptide (0.1mmol scale) in < 30 minutes with < 100mL total waste. This technology can be readily extended to produce a 50 mer peptide in 3.5 hours. It has also permitted scale up into the kilogram range with ease.

In this presentation, the most recent advances in microwave assisted SPPS are reported.  Topics include: (1) review of current methodology, (2) introduction of new methodology for GMP high-throughput synthesis, and (3) scale up from milligram to kilogram quantities of peptide.  The robust nature of these methodologies is demonstrated with the high-purity syntheses of a number of pharmaceutically relevant peptides as well post-synthetically sequences.

  • Learn about how modern instrumentation revolutionizes peptide synthesis
  • See how large scale cGMP peptide synthesis is achievable with microwave technology
  • Document impurity profiles in days instead of weeks
  • Discover how to offer next day custom and catalogue SPPS services

Presented by:

Giorgio Marini studied organic chemistry and pharmaceutical technologies at the University of Milan where he got his degree in 1997.

After a few years working as a clinical monitor for an American Clinical Research Organization, he joined the field of scientific instrumentation, working for several international companies like Buchi Italy, Buchi Labortechnik AG and Biotage Corporation as a sales representative and product manager.

In 2004 he has joined CEM Corporation as a Life Science Technical Specialist, contributing to the promotion of Microwave Solid Phase Peptide Synthesis all over Europe and around the world.

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